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The in vivo therapeutic effects of lidamycin and mitomycin C were determined by transplantable hepatoma 22 H22 in mice and human hepatoma BEL xenografts in athymic mice. Expression of apoptosis related molecules e. The reasons for unsuccessful treatment of solid tumors included poor penetration into tumors and the severe immune responses [26] — [28]. Crosslinking of CD20 by antibodies has been reported to induce a redistribution of CD20 molecules to specialized microdomains at the plasma membrane known as lipid rafts. Therefore, the effects of some monospecific antibodies and tyrosine kinase inhibitors that block EGFR or HER2 function, such as cetuximab, trastuzumab, gefitinib, and erlotinib on esophageal carcinoma have been examined, but the efficacy is limited so far [19] — [22].

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Follow LettersOncology. The photographs and videos that were taken of Linsey when she was 15, 16 and 18 are available at Linsey's UK website but not her US one.

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